Advanced Therapies

Nicole Dale

Clinical Trials in Depression Reveal New R&D Priorities in 2026

Pharmatica image representing clinical trials in depression, antidepressant development, patient data, and emerging CNS therapies.

Clinical trials in depression reveal a broader R&D landscape, from antidepressants and NMDA approaches to biological data and precision psychiatry.

Nicole Dale

CMS Finalises Medicare GLOBE to Rewrite Drug Pricing

Pharmatica image showing a pharmaceutical medicines vial and abstract international pricing benchmark concept representing the Medicare GLOBE drug payment model.

The Medicare GLOBE drug payment uses international drug prices to reshape selected Medicare Part B rebates. Here is what the final CMS rule means for pharma.

Nicole Dale

Bioprocessing Is Becoming a Smarter Manufacturing System

Pharmatica image of a pharmaceutical bioprocessing facility with stainless-steel bioreactors, process sensors, and connected digital manufacturing systems.

Bioprocessing is becoming more connected, automated, and data-driven. Here is what smarter process control means for biopharma manufacturing.

Nicole Dale

What Sponsors Need to Know About UK Combined Review 2026

Pharmatica image for UK Combined Review clinical trial approval showing coordinated MHRA and ethics assessment through a unified CTIMP regulatory pathway.

UK Combined Review unifies MHRA and ethics review for CTIMPs, reshaping approval timelines, submissions, and sponsor planning under UK trial reform.

Nicole Dale

Why Formulation Development Now Starts With Manufacturing

Pharmatica image of pharmaceutical formulation development connecting drug formulation science with advanced manufacturing and process control.

Formulation development is moving beyond drug delivery to shape manufacturing, quality, scale-up, and supply resilience across modern pharmaceutical operations.

Nicole Dale

MHRA Clarifies Licensing for Microbiome-Based Medicines

Pharmatica image of abstract red microbial imagery on a soft white background, representing microbiome-based medicinal product UK regulation.

The MHRA has set out its position on microbiome-based medicinal products, confirming that a clear UK licensing route already exists for these therapies.

Nicole Dale

Nanocarriers Target the Eye for Better Ocular Drug Delivery

Pharmatica image representing ocular drug delivery using nanocarriers to improve therapeutic targeting of the eye and retinal tissues.

Ocular drug delivery faces major biological barriers. Nanocarriers could improve bioavailability, tissue targeting, controlled release, and treatment for difficult eye diseases.

Nicole Dale

Collaborating for R&D Success in Drug Discovery

Pharmatica realistic representation of collaboration in drug discovery showing interlocking green and blue puzzle pieces with a DNA helix emerging from their center, capsules in front, a glowing molecular data screen behind, and a 3D molecular model to the right on a bright white background.

Collaboration in drug discovery can shape pharma R&D success. Explore the evidence on pharma partnerships, knowledge sharing, governance, and innovation.

Nicole Dale

Psychedelic Drug Discovery Gets a New Preclinical Framework

Pharmatica detailed rendering of a neuron firing electrical impulses through dendrites and axons in vivid green tones, symbolising neural connectivity and communication in psychedelic drug discovery, neuroplasticity, 5-HT2A receptor pharmacology, CNS drug development, psychoplastogens, and therapeutic neuroscience research.

Find out how psychedelic drug discovery is evolving through receptor pharmacology, behavioural science, and neuroplasticity to develop safer CNS therapeutics.

Nicole Dale

Using Machine Learning for Lipid Nanoparticle Design

Machine learning for lipid nanoparticles illustrating AI-driven optimisation of lipid nanoparticle formulations for mRNA drug delivery, RNA therapeutics, nanomedicine, and next-generation drug discovery.

Read about machine learning for lipid nanoparticle design used to improve cell, gene, and RNA drug delivery and help optimise next-generation therapeutics.

Nicole Dale

GLP-1 Drug Discovery Success Transformed Pharmaceutical R&D

Pharmatica photorealistic illustration of GLP-1 drug discovery showing peptide molecules, metabolic signalling pathways, and obesity treatment research in a modern pharmaceutical laboratory.

From gut hormones to global therapeutics, GLP-1 drug discovery transformed obesity treatment through peptide engineering and incretin biology translation.

Nicole Dale

Optimising Preclinical Pharmacology for Oncology NMEs

Oncology researcher performing preclinical pharmacology testing for new molecular entities (NMEs), illustrating oncology drug development, translational research, biomarker discovery, and advanced preclinical model optimisation.

Over 90% of oncology NMEs that succeed in animal studies fail in clinical trials. This analysis examines how to optimise preclinical pharmacology models to improve translational success.