Translational & Pre-clinical Research

Nicole Dale

GLP-1 Obesity Evidence Is Changing Clinical Development

Pharmatica GLP-1 obesity clinical development visual showing metabolic therapy, clinical research, and evidence generation.

GLP-1 obesity clinical evidence is reshaping drug development as efficacy, safety, cardiovascular outcomes, and treatment durability become critical.

Nicole Dale

Liver-Chip Supported Drug Discovery Moves to FDA Qualification

Pharmatica image of a human liver-chip platform used for liver-chip drug discovery and preclinical drug toxicity assessment in a pharmaceutical laboratory.

Liver-chip supported drug discovery is moving closer to regulatory acceptance as Emulate advances FDA ISTAND qualification for human-relevant DILI assessment.

Nicole Dale

Why Gynaecological Cancers Are Some of Pharma’s Most Important Challenges

Pharmatica image of a medical laboratory background featuring a 3D medical illustration of the female reproductive system with glowing ovaries and uterus, representing gynaecological cancer pharma research.

Gynaecological cancers remain a major pharma challenge. Explore how disease burden, access, tumour biology, and precision medicine are shaping oncology R&D.

Nicole Dale

Why Does the True Impact of AI in Drug Discovery Lag?

Pharmatica image showing dense green data nodes that converge on one illuminated point, symbolising AI in drug discovery.

AI in drug discovery keeps making headlines, but clinical success rates barely move. A new Nature Reviews Perspective explains why, and what pharma should do next.

Nicole Dale

AI-Driven Digital Organisms Could Change Drug Discovery

Pharmatica image of an AI-driven digital organism concept showing a realistic human cell connected to computational data pathways for virtual biology and drug discovery.

AI-driven digital organisms could transform drug discovery by simulating biology across scales. Explore GenBio AI's AIDO vision and the virtual cell.

Nicole Dale

Better Predictive Modelling for Better Drug Development

Pharmatica image showing AI-powered pharmaceutical drug discovery environment showing predictive modelling, molecular research, and connected scientific data.

Discover how predictive modelling, QSP, AI, and systems biology creates better drug development by connecting biological evidence with better predictions.

Nicole Dale

Could q-CAR Redefine Drug Discovery?

Pharmatica image for q-CAR drug discovery showing dynamic protein conformations, ligand binding, and AI-driven molecular analysis.

Find out how q-CAR drug discovery moves beyond static protein structures by linking protein dynamics, ligand activity, and AI to precision drug design.

Nicole Dale

Nanocarriers Target the Eye for Better Ocular Drug Delivery

Pharmatica image representing ocular drug delivery using nanocarriers to improve therapeutic targeting of the eye and retinal tissues.

Ocular drug delivery faces major biological barriers. Nanocarriers could improve bioavailability, tissue targeting, controlled release, and treatment for difficult eye diseases.

Nicole Dale

AI Creates New Viruses? Not Quite. AI-Designed Bacteriophages

Pharmatica image of AI-designed bacteriophage research in a biotech laboratory showing genome analysis, AI genome design, and phage development.

AI-designed bacteriophages show how genome models could create new antibacterial therapies while forcing pharma to rethink biological AI governance and biosecurity.

Nicole Dale

Collaborating for R&D Success in Drug Discovery

Pharmatica realistic representation of collaboration in drug discovery showing interlocking green and blue puzzle pieces with a DNA helix emerging from their center, capsules in front, a glowing molecular data screen behind, and a 3D molecular model to the right on a bright white background.

Collaboration in drug discovery can shape pharma R&D success. Explore the evidence on pharma partnerships, knowledge sharing, governance, and innovation.

Nicole Dale

Psychedelic Drug Discovery Gets a New Preclinical Framework

Pharmatica detailed rendering of a neuron firing electrical impulses through dendrites and axons in vivid green tones, symbolising neural connectivity and communication in psychedelic drug discovery, neuroplasticity, 5-HT2A receptor pharmacology, CNS drug development, psychoplastogens, and therapeutic neuroscience research.

Find out how psychedelic drug discovery is evolving through receptor pharmacology, behavioural science, and neuroplasticity to develop safer CNS therapeutics.

Nicole Dale

Using Machine Learning for Lipid Nanoparticle Design

Machine learning for lipid nanoparticles illustrating AI-driven optimisation of lipid nanoparticle formulations for mRNA drug delivery, RNA therapeutics, nanomedicine, and next-generation drug discovery.

Read about machine learning for lipid nanoparticle design used to improve cell, gene, and RNA drug delivery and help optimise next-generation therapeutics.